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Hepatitis C viraemia in adults with type 2 autoimmune hepatitis

✍ Scribed by Dr. J. A. Garson; M. Lenzi; C. Ring; F. Cassani; G. Ballardini; M. Briggs; R. S. Tedder; F. B. Bianchi

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
475 KB
Volume
34
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Sera from 14 patients with type 2 autoimmune hepatitis (anti‐LKM, positive) were investigated for evidence of hepatitis C virus (HCV) infection. Antibodies to HCV were detected in 13 patients by both commercial and β€œin‐house” ELlSAs and also by a second generation recombinant immunoblot assay. Nine of the 13 (69%) anti‐HCV positive patients were shown to be viraemic by a polymerase chain reaction‐based assay for serum HCV RNA. Neither anti‐HCV nor serum HCV RNA were detected in any of 6 controls with primary biliary cirrhosis or in 39 healthy blood donors. These findings strongly suggest a role for HCV in the pathogenesis of type 2 autoimmune hepatitis.

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