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Different enantioselectivity and regioselectivity of the cytosolic and microsomal epoxide hydrolase catalyzed hydrolysis of simple phenyl substituted epoxides

✍ Scribed by Giuseppe Bellucci; Cinzia Chiappe; Antonio Cordoni; Franco Marioni

Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 346 KB
Volume: 35
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)73156-x

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✦ Synopsis

Abstractt The cytoaolic (cEH) mad the micmsonul cpoxidc bydtolasc (mEH) hydrolyac rtytenc oxide and tram-1-pbcnylproper oxide with different enmtio~elcctivity and ~~gioxelectivity. While mEEI always leads to l rcgiospccific and enxntio4&ive opening rt the non-bcnxylic oxinnc a&on. CEH given x aon-rc&m&ctive and non-cnmtiosclcctive attack to stymnc oxide l d l a+quciGc and noacnantioselcctive attack at the bcnxylic carbon of l-phnylpmpcnc oxide.

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