Different effects of cyclosporine and tacrolimus on the activation of mesangial metalloproteinases and their inhibitors
β Scribed by G Hampel; R Hosseini; K Jung
- Book ID
- 117238459
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 219 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0041-1345
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Abbreviations: AUC, area under the curve; AUC 0-1 , area under the curve from time 0 to infinity; CI, confidence interval(s); CL/F, apparent clearance; C max , maximum concentration; CRU, Clinical Research Unit; CYP3A, cytochrome P450 3A; DN, dose-normalized; F, oral bioavailability; GLS mean ratio(
Matrix metalloproteinase (MMP) activity has been associated with tumor invasion and metastasis in many different tumor types, but recent studies also support a role for these enzymes in earlier stages of the tumor progression continuum. Specifically, the expression pattern of MMPs in benign human an