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Difference in the effects of ursodeoxycholate and its taurine conjugate on the biliary excretion of sulfobromophthalein in the rat

✍ Scribed by Kanai, S.; Kitani, K.; Sato, Y.

Book ID: 122154516
Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 337 KB
Volume: 10
Category: Article
ISSN: 0168-8278
DOI: 10.1016/0168-8278(90)90048-V

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The clinical effectiveness of ursodeoxycholate in the treatment of liver disease may be limited by its poor absorption and extensive biotransformation. Because in vitro and in vivo studies suggest that the more hydrophilic bile acid tauroursodeoxycholate has greater beneficial effects than ursodeoxy