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Difference in liver and serum malathion carboxylesterase and glucose-6-phosphatase in detecting carbon tetrachloride-induced liver damage in rats

✍ Scribed by M. T. Brondeau; C. Coulais; J. de Ceaurriz

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 315 KB
Volume: 11
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550110609

No coin nor oath required. For personal study only.

✦ Synopsis

Microsome, cytosol and serum malathion carboxylesterase (MaCEst) activity was assessed in rats after single i.p. administration of carbon tetrachloride (CCIJ) in doses ranging from 0.05 to 1 ml kg-I. MaCEst activities were compared with those of glucose-6-phosphatase (G6-Pase) as an indicator of endoplasmic reticulum damage and serum glutamate dehydrogenase (GLDH) and sorbitol dehydrogenase (SHD) as indicators of liver cytolysis. The data showed a dose-dependent increase in GLDH and SDH serum activities (175% and 68%) from 0.05 ml kg-'; an increase in serum G6-Pase (31%) and a decrease in microsomal G6-Pase (38%) was apparent only after 0.5 or 1.0 ml kg-' doses. MaCEst activity was unaffected. The results demonstrate that, under these experimental conditions, serum and subcellular measurements of MaCEst activity failed to reveal the liver toxicity of CCI+

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