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Difference in cytotoxicity of (22R)-cholest-5-ene-3β,7α,22-triol and (22R)-cholest-5-ene-3β,7β,22-triol is not explained by different patterns of metabolites

✍ Scribed by Kirsten Muri Boberg; Ingrid Smith-Kielland; Arnulv Slabursvik; Oddvar Stokke


Book ID
116007660
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
346 KB
Volume
33
Category
Article
ISSN
0022-4731

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(25R)-5 alpha-Cholest-8(14)-ene-3 beta,15 beta,26-triol (III) was prepared by reduction of (25R)-3 beta,26-diacetoxy-5 alpha-cholest-8(14)-en-15-one with sodium borohydride followed by treatment of the crude product with lithium aluminium hydride. The trihydroxysterol III, a potential metabolite of