An improved synthesis of (20R,22R)-cholest-5-ene-3β,20,22-triol, an intermediate in steroid hormone formation and an activator of nuclear orphan receptor LXRα

ChemInform Abstract: An Alternative Synt

ChemInform Abstract: An Alternative Synthesis of 4,4-Dimethyl-5α-cholesta-8,14,24-trien-3β-ol, an Intermediate in Sterol Biosynthesis and a Reported Activator of Meiosis and of Nuclear Orphan Receptor LXRα.

✍ B. RUAN; W. K. WILSON; G. J. JUN. SCHROEPFER 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 38 KB 👁 1 views

An Alternative Synthesis of 4,4-Dimethyl-5α-cholesta-8,14,24-trien-3β-ol, an Intermediate in Sterol Biosynthesis and a Reported Activator of Meiosis and of Nuclear Orphan Receptor LXRα. -The title compound (V) is synthesized by a simple six-step procedure. A key step in this synthesis is the highly