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Dietary restriction does not prevent nigrostriatal degeneration in the 6-hydroxydopamine model of Parkinson's disease

โœ Scribed by M.T. Armentero; G. Levandis; P. Bramanti; G. Nappi; F. Blandini


Book ID
116459343
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
231 KB
Volume
212
Category
Article
ISSN
0014-4886

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Progressive degeneration of dopamine neu
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## Abstract 6โ€Hydroxydopamine (6โ€OHDA), a neurotoxin that causes the death of dopamine (DA) neurons, is commonly used to produce experimental models of Parkinson's disease (PD) in rodents. In the rat model of PD first described by Sauer and Oertel, DA neurons progressively die over several weeks fo