Both human porphyria cutanea tarda and experimental hexachlorobenzene-induced porphyria are associated with hepatic injury and are potentiated by excess hepatic iron. The mechanisms whereby cellular injury occurs and the synergistic role of iron overload are unknown. In the present experiments, we s
✦ LIBER ✦
Dietary iron overload and induced lipid peroxidation are associated with impaired plasma lipid transport and hepatic sterol metabolism in rats
✍ Scribed by Sylvain Brunet; Louise Thibault; Edgard Delvin; Wagner Yotov; Moïse Bendayan; Emile Levy
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 461 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0270-9139
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In both hereditary hemochromatosis (HHC) and in the various forms of secondary hemochromatosis, there is a pathological expansion of total body iron stores, due mainly to an inappropriate increase in absorption of dietary iron (1-3). The liver is the major recipient of this excess absorbed iron, and