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Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study

✍ Scribed by Carlos A. González; Noemie Travier; Leila Luján-Barroso; Xavier Castellsagué; F. Xavier Bosch; Esther Roura; H. Bas Bueno-de-Mesquita; Domenico Palli; Heiner Boeing; Valeria Pala; Carlotta Sacerdote; Rosario Tumino; Salvatore Panico; Jonas Manjer; Joakim Dillner; Göran Hallmans; Lennart Kjellberg; María-José Sanchez; Jone M. Altzibar; Aurelio Barricarte; Carmen Navarro; Laudina Rodriguez; Naomi Allen; Timothy J. Key; Rudolf Kaaks; Sabine Rohrmann; Kim Overvad; Anja Olsen; Anne Tjønneland; Christian Munk; Susanne Krüger Kjaer; Petra H.M. Peeters; Fränzel J.B. van Duijnhoven; Françoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Antonia Trichopoulou; Vasiliki Benetou; Androniki Naska; Eiliv Lund; Dagrun Engeset; Guri Skeie; Silvia Franceschi; Nadia Slimani; Sabina Rinaldi; Elio Riboli

Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
168 KB
Volume
129
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Some dietary factors could be involved as cofactors in cervical carcinogenesis, but evidence is inconclusive. There are no data about the effect of fruits and vegetables intake (F&V) on cervical cancer from cohort studies. We examined the association between the intake of F&V and selected nutrients and the incidence of carcinoma in situ (CIS) and invasive squamous cervical cancer (ISC) in a prospective study of 299,649 women, participating in the European Prospective Investigation into Cancer and Nutrition study. Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CI). A calibration study was used to control measurement errors in the dietary questionnaire. After a mean of 9 years of follow‐up, 253 ISC and 817 CIS cases were diagnosed. In the calibrated model, we observed a statistically significant inverse association of ISC with a daily increase in intake of 100 g of total fruits (HR 0.83; 95% CI 0.72–0.98) and a statistically nonsignificant inverse association with a daily increase in intake of 100 g of total vegetables (HR 0.85: 95% CI 0.65–1.10). Statistically nonsignificant inverse associations were also observed for leafy vegetables, root vegetables, garlic and onions, citrus fruits, vitamin C, vitamin E and retinol for ISC. No association was found regarding beta‐carotene, vitamin D and folic acid for ISC. None of the dietary factors examined was associated with CIS. Our study suggests a possible protective role of fruit intake and other dietary factors on ISC that need to be confirmed on a larger number of ISC cases.

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