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Dietary arginine alters time of symptom onset in Huntington’s disease transgenic mice

✍ Scribed by A.Wallace Deckel; Paige Volmer; Ronald Weiner; Keith A. Gary; Jonathan Covault; Daniel Sasso; Nurit Schmerler; Daniela Watts; Zhige Yan; Ilana Abeles


Book ID
113995286
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
349 KB
Volume
875
Category
Article
ISSN
0006-8993

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Glutamate excitotoxicity has been suggested to contribute to the pathogenesis of Huntington's disease (HD). Riluzole is a substance with glutamate antagonistic properties that is used for neuroprotective treatment in amyotrophic lateral sclerosis and which is currently tested in clinical trials for