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Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates

✍ Scribed by Roderick H Dashwood; Emily Ho


Book ID
109381382
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
54 KB
Volume
66
Category
Article
ISSN
0029-6643

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Dietary agents as histone deacetylase in
✍ Melinda C. Myzak; Emily Ho; Roderick H. Dashwood πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 109 KB

## Abstract In cancer cells, an imbalance often exists between histone acetyltransferase (HAT) and histone deacetylase (HDAC) activities, and various drug companies are actively seeking competitive HDAC inhibitors for chemotherapeutic intervention. Cancer cells appear to be more sensitive than nont