Diels–Alder reactions of 3-(1H-tetrazol-5-yl)-nitrosoalkenes: synthesis of functionalized 5-(substituted)-1H-tetrazoles
✍ Scribed by Susana M.M. Lopes; Francisco Palacios; Américo Lemos; Teresa M.V.D. Pinho e Melo
- Book ID
- 113928948
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 909 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0040-4020
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This work describes the first and unprecedented examples of inverse electron demand Diels-Alder reactions of 5-(1-nitrosovinyl)-1-phenyl-1H-tetrazole, generated in situ from the corresponding bromooxime, with electron rich alkenes and heterocycles, providing in good overall yields tetrazolyl-1,2-oxa
## Abstract A new and convenient synthesis of a variety of __N__‐ and __S__‐substituted tetrazoles has been developed via azide and Mannich reaction methods. Compounds were characterized by elemental analysis, MALDI MS, and ^1^H NMR data. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:637–643, 2