Efficient synthesis of 1-substituted-4-phenyl-1, 4-dihydro-5H-tetrazole-5-thione and (1-phenyl-1H-tetrazol-5-yl)thioacetyl derivatives
β Scribed by Walid Fathalla; Ibrahim A. I. Ali
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 223 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1042-7163
- DOI
- 10.1002/hc.20353
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β¦ Synopsis
Abstract
A new and convenient synthesis of a variety of Nβ and Sβsubstituted tetrazoles has been developed via azide and Mannich reaction methods. Compounds were characterized by elemental analysis, MALDI MS, and ^1^H NMR data. Β© 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:637β643, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20353
π SIMILAR VOLUMES
In contrast to the 5-bromo-and 5-iodo-I-phenyl-IN-tetrazoles [7], the fluoro analogue has not been described. The conversion of 5-chloro-l-(phenylrnethyl)-lH-tetrazole to the corresponding fluorotetrazole using K F and [18]crown-6 in MeCN has been reported [8]; however, under these reaction conditio