Die 8p11-myeloproliferative Erkrankung
✍ Scribed by Reiter, Andreas ;Hehlmann, Rüdiger ;Goldman, John M. ;Cross, Nicholas C. P.
- Publisher
- Springer
- Year
- 1999
- Tongue
- German
- Weight
- 455 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0723-5003
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Fourteen cases of an atypical myeloproliferative disorder associated with consistent translocations involving 8p11-12 have previously been described. A t(8;13)(p11;q11-12) was the most common, but variant t(8;9)(p11-12;q32-34) and t(6;8)(q27;p12) were also reported. Here we have used a series of yea
## Abstract The 8p11 myeloproliferative syndrome (EMS) is an aggressive hematological malignancy caused by the fusion of diverse partner genes to fibroblast growth factor receptor 1 (__FGFR1__). The partner proteins promote dimerization and ligand‐independent activation of __FGFR1__‐encoded tyrosin