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Characterization of a t(8;13)(p11;q11-12) in an atypical myeloproliferative disorder

✍ Scribed by Damian Smedley; Gino Somers; Deon Venter; Chung Wo Chow; Colin Cooper; Janet Shipley

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 197 KB
Volume: 21
Category: Article
ISSN: 1045-2257
DOI: 10.1002/(sici)1098-2264(199801)21:1<70::aid-gcc9>3.0.co;2-5

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✦ Synopsis

Fourteen cases of an atypical myeloproliferative disorder associated with consistent translocations involving 8p11-12 have previously been described. A t(8;13)(p11;q11-12) was the most common, but variant t(8;9)(p11-12;q32-34) and t(6;8)(q27;p12) were also reported. Here we have used a series of yeast artificial chromosomes (YACs) derived from the 8p11 and 13q11-12 regions to analyse one of the t(8;13) cases by fluorescence in situ hybridization (FISH). YACs flanking the 13q11-12 breakpoint and spanning the 8p11 breakpoint have been isolated. These YACs will facilitate characterization of the genes involved in this rearrangement.

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