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Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS

✍ Scribed by M.José Gómez-Lechón; Xavier Ponsoda; Enrique O’Connor; Teresa Donato; José V. Castell; Ramiro Jover

Book ID
113486900
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
556 KB
Volume
66
Category
Article
ISSN
0006-2952

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Acetaminophen overdose causes massive hepatic failure via mechanisms involving glutathione depletion, oxidative stress, and mitochondrial dysfunction. The ultimate target of acetaminophen causing cell death remains uncertain, and the role of apoptosis in acetaminophen-induced cell killing is still c