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Diborane reduction of carboxyl groups in carbohydrates

✍ Scribed by F. Smith; A.M. Stephen

Book ID
104235026
Publisher
Elsevier Science
Year
1960
Tongue
French
Weight
337 KB
Volume
1
Category
Article
ISSN
0040-4039

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✦ Synopsis

ESTER and lactone groups in carbohydrate compounds may be reduced by complex metal hydrides in aqueous solution 1,2 or in dry ether-type solvents.3g4y5 Reduction of carboxyl groups may also be effected by lithium aluminum hydride6 and related metal hydrides, but the method is limited to carboxylic acids soluble in organic solvents which are not affected by the reducing agent. 7 Consequently it has been possible to convert a methylated acidic polysaccharide into a methylated neutral polysaccharide' by carryix.g out the reduction in tetrahydrofuran but our attempts to reduce an acylated acidic polysaccharide have failed because the ester groups are attacked first and as a result acidic polysaccharide

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