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Dibenzo[b,f]oxepin-10(11H)-one and dibenzo[b,f]thiepin-10(11H)-one as useful synthons in the synthesis of various dibenzo[e,h]azulenes

✍ Scribed by Dijana Pešić; Ivana Ozimec Landek; Renata Rupčić; Marina Modrić; Iva Džapo [1]; Rudolf Trojko [2]; Mladen Merćep [3]; Milan Mesić

Book ID
112131746
Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
304 KB
Volume
49
Category
Article
ISSN
0022-152X

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✍ Charles S. Elmore; Peter N. Dorff; J. Richard Heys 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 142 KB 👁 1 views

## Abstract Clozapine has been demonstrated to bind covalently to proteins as a result of metabolic activation that has been proposed to be a precursor to the serious side effects including death that occur in a small percentage of the population. The covalent modification of proteins by clozapine