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ChemInform Abstract: Dibenzo[b,f]oxepin-10(11H)-one and Dibenzo[b,f]thiepin-10(11H)-one as Useful Synthons in the Synthesis of Various Dibenzo[e,h]azulenes

✍ Scribed by Dijana Pesic; Ivana Ozimec Landek; Renata Rupcic; Marina Modric; Iva Dzapo; Rudolf Trojko; Mladen Mercep; Milan Mesic

Book ID
112048732
Publisher
John Wiley and Sons
Year
2012
Weight
18 KB
Volume
43
Category
Article
ISSN
0931-7597

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## Abstract Clozapine has been demonstrated to bind covalently to proteins as a result of metabolic activation that has been proposed to be a precursor to the serious side effects including death that occur in a small percentage of the population. The covalent modification of proteins by clozapine