Diazabicycloalkanes with nitrogen atoms in bridgehead positions. 15. Reactions of benzo[b]-1,4-diazabicyclo[2.2.2]octene monoquaternary salt derivatives with nucleophilic reagents

✍ Scribed by N. P. Luk'yanchuk; N. I. Sagalaeva; V. K. Soboleva; G. V. Shishkin

• Publisher: Springer US
• Year: 1987
• Tongue: English
• Weight: 588 KB
• Volume: 23
• Category: Article
• ISSN: 0009-3122
• DOI: 10.1007/bf00475654

✦ Synopsis

3,

5,

isoquinoline (Ilia). A mixture of 2.27 g (i0 mmole) of compound IIa and 0.68 ml (15 mmole) of hydrazine hydrate was boiled in ethanol for 3 h. On cooling, hydrazone IIIa formed a precipitate, which was filtered off, dried, and recrystallized.

2-Semicarbazono-3-oxo-5,5-dimethyl-2,3~5,6-tetrahydropyrrolo[2,1-a]isoquinollne (IIIb).

A 2.27-g (10 mmole) portion of pyrroledione IIa was dissolved on heating in 30 ml of 70% ethanol; 1.12 g (lOmmole) of semicarbazide hydrochlorlde was dissolved in 20 ml of water and 1.5 g of sodium acetate and the aqueous alcoholic solution of compound IIa were added. The mixture was agitated and boiled for 2 h. On cooling, substance IIlb precipitated out, and it was filtered off, dried, and recrystallized. .

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