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Diastereoselectivity in heterogeneous catalytic hydrogenation of Baylis–Hillman adducts. Total synthesis of (±)-sitophilate

✍ Scribed by Cristiano R Mateus; Melissa P Feltrin; Ana M Costa; Fernando Coelho; Wanda P Almeida

Book ID
108371301
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
162 KB
Volume
57
Category
Article
ISSN
0040-4020

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Diastereoselective heterogeneous catalyt
Diastereoselective heterogeneous catalytic hydrogenation of Baylis–Hillman adducts
✍ Cristiano R Mateus; Wanda P Almeida; Fernando Coelho * 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 176 KB

We describe herein our results concerning a highly diastereoselective heterogeneous hydrogenation of Baylis-Hillman adducts obtained from aromatic aldehydes. The results obtained are complementary to those already described for homogeneous catalytic hydrogenation reactions.

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✍ Giovanni W. Amarante; Mayra Cavallaro; Fernando Coelho 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 285 KB

We disclose herein a new approach for the highly diastereoselective total synthesis of the anti-tumoral agent (±)-Spisulosine. The synthesis was accomplished in seven steps with an overall yield of 10%. The key step involves the transformation of a Morita-Baylis-Hillman into an acyloin, which was su