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A Morita–Baylis–Hillman adduct allows the diastereoselective synthesis of styryl lactones

✍ Scribed by Paulo H.S. Paioti; Fernando Coelho

Book ID
113930010
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
504 KB
Volume
52
Category
Article
ISSN
0040-4039

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Highly diastereoselective total synthesi
Highly diastereoselective total synthesis of the anti-tumoral agent (±)-Spisulosine (ES285) from a Morita–Baylis–Hillman adduct
✍ Giovanni W. Amarante; Mayra Cavallaro; Fernando Coelho 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 285 KB

We disclose herein a new approach for the highly diastereoselective total synthesis of the anti-tumoral agent (±)-Spisulosine. The synthesis was accomplished in seven steps with an overall yield of 10%. The key step involves the transformation of a Morita-Baylis-Hillman into an acyloin, which was su