Enantiocontrolled total synthesis of the
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Itsuki Yamamura; Yoko Fujiwara; Toshihiro Yamato; Osamu Irie; Kozo Shishido
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Article
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1997
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Elsevier Science
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French
⚖ 263 KB
An efficient and enantiocontrolled synthesis of triptoquinone B and C, which possess interleukin-1 inhibitory activity, has been accomplished employing the lipase-catalyzed kinetic resolution and a highly diastereoselective radical cyclization as key synthetic steps. In addition, the first total syn