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Enantiocontrolled total synthesis of the diterpenoids, triptoquinone B, C and triptocallol

✍ Scribed by Itsuki Yamamura; Yoko Fujiwara; Toshihiro Yamato; Osamu Irie; Kozo Shishido

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
263 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient and enantiocontrolled synthesis of triptoquinone B and C, which possess interleukin-1 inhibitory activity, has been accomplished employing the lipase-catalyzed kinetic resolution and a highly diastereoselective radical cyclization as key synthetic steps. In addition, the first total synthesis of hiptocallol has been achieved utilizing the same strategy.

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