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Diastereoselective Synthesis of Heteroaromatic Glycine Derivatives

✍ Scribed by Trygve Andreassen; Lars-Kristian Hansen; Odd R. Gautun

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 170 KB
Volume: 2008
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.200800622

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✦ Synopsis

Abstract

A TMSOTf promoted addition of an N‐tert‐butanesulfinyl α‐imino ester to five‐membered aromatic heterocycles furnishes optically active heteroaromatic glycine derivatives with moderate‐to‐good yield in diastereomeric ratios up to 99 %. The absolute configuration of two of the addition products were solved by X‐ray analysis. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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