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Diastereoselective Synthesis of 1-Benzyltetrahydroisoquinoline Derivatives from Amino Acids via 1,4 Chirality Transfer. Part 1

✍ Scribed by Zawadzka, Anna; Leniewski, Andrzej; Maurin, Jan K.; Wojtasiewicz, Krystyna; Czarnocki, Zbigniew


Book ID
120444453
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
44 KB
Volume
3
Category
Article
ISSN
1523-7060

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Diastereoselective Synthesis of 1-Benzyl
✍ Anna Zawadzka; Andrzej Leniewski; JanΒ K. Maurin; Krystyna Wojtasiewicz; Aleksand πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 239 KB πŸ‘ 2 views

## Abstract L‐Amino acids (L‐Ala, L‐Phe, L‐Val, L‐Pro) were used as a source of chirality in the diastereoselective synthesis of tetrahydroisoquinoline derivatives. The key step was the Pictetβˆ’Spengler condensation of ketoamides **4** and **10**, which proceeded under very mild conditions. L‐Ala, L

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