Diastereoselective Reduction of Cyclic Imines and b-Enamino Esters
✍ Scribed by Lhommet, Gérard; Vo Thanh, Giang; Célérier, Jean-Pierre; Fleurant, Anne; Grandjean, Cyrille; Rosset, Sylvie
- Book ID
- 118129710
- Publisher
- Japan Institute of Heterocyclic Chemistry
- Year
- 1996
- Tongue
- English
- Weight
- 94 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0385-5414
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📜 SIMILAR VOLUMES
Catalytic and chemical reductions of chiral pyrrolidine 13-enamino esters provides corresponding [3-amino esters with good to moderate diastereomer excesses. The unexpected major diastereomer 5 comes from a reduction process which amounts to an anti hydrogen addition.
The preparation of chiral pyrrolidine and piperidine b-enamino esters starting from v-halogeno b-keto esters, their diastereoselective reduction and the subsequent cleavage of the chiral auxiliary are described.