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Chiral Heterocyclic β-Enamino Esters: Convenient Synthesis and Diastereoselective Reduction.

✍ Scribed by Sandrine Calvet; Olivier David; Corinne Venucci-Bacque; Marie-Claude Fargeau-Bellassoued; Gerard Lhommet


Publisher
John Wiley and Sons
Year
2003
Weight
147 KB
Volume
34
Category
Article
ISSN
0931-7597

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📜 SIMILAR VOLUMES


Chiral heterocyclic β-enamino esters: co
✍ Sandrine Calvet; Olivier David; Corinne Vanucci-Bacqué; Marie-Claude Fargeau-Bel 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 205 KB

The preparation of chiral pyrrolidine and piperidine b-enamino esters starting from v-halogeno b-keto esters, their diastereoselective reduction and the subsequent cleavage of the chiral auxiliary are described.

Chiral cyclic β-amino esters. Part II: S
✍ J. Blot; A. Bardou; C. Bellec; M.-C. Fargeau-Bellassoued; J.P. Célérier; G. Lhom 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 182 KB

Catalytic and chemical reductions of chiral pyrrolidine 13-enamino esters provides corresponding [3-amino esters with good to moderate diastereomer excesses. The unexpected major diastereomer 5 comes from a reduction process which amounts to an anti hydrogen addition.