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A short and convenient synthesis of chiral heterocyclic β-enamino esters from halogeno acetylenic esters

✍ Scribed by Olivier David; Marie-Claude Fargeau-Bellassoued; Gérard Lhommet

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
72 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient synthesis of chiral pyrrolidine and piperidine enamino esters is described in one step from methyl halogeno alcynoate and (S)-1-phenylethylamine or (S)-phenylglycinol.

📜 SIMILAR VOLUMES

Chiral heterocyclic β-enamino esters: co
Chiral heterocyclic β-enamino esters: convenient synthesis and diastereoselective reduction
✍ Sandrine Calvet; Olivier David; Corinne Vanucci-Bacqué; Marie-Claude Fargeau-Bel 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 205 KB

The preparation of chiral pyrrolidine and piperidine b-enamino esters starting from v-halogeno b-keto esters, their diastereoselective reduction and the subsequent cleavage of the chiral auxiliary are described.