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Diastereoselective reduction of acyclic hydroxyketones and diketones with an indium hydride reagent

✍ Scribed by Masafumi Yamada; Tomoaki Horie; Masao Kawai; Hatsuo Yamamura; Shuki Araki

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 323 KB
Volume: 53
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(97)10024-2

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✦ Synopsis

Hydroxyketones and diketones have been reduced with lithium indium hydride to give meso-diols selectively, c¢-Hydroxyketones and 0c-diketones are reduced to meso-l,2-diols with high diastereoselectivities, whereas the selectivities of ~hydroxyketones and [~diketones are less satisfactory.

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