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Diastereoselective Construction of 7-Methylenebicyclo[3.2.1]oct-3-en-2-one Derivatives by Palladium-Catalyzed Cyclization of Propargylic Acetates with 2-Oxocyclohex-3-enecarboxylates

✍ Scribed by Yoshida, Masahiro; Sugimura, Chiyuki; Shishido, Kozo


Book ID
127394705
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
948 KB
Volume
13
Category
Article
ISSN
1523-7060

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## Abstract 2‐Bromobenzaldehyde reacts with an excess of primary amines under a carbon monoxide in the presence of a catalytic amount of bis(triphenylphosphine)palladium(II) chloride together with triethylamine to give the corresponding 3‐(alkylamino)isoindolin‐1‐ones in good yields.