Syntheses of six novel phosphine oxide chiral auxiliaries are described. The auxiliaries are composed of the diphenylphosphinoyl (Ph2PO) group and either proline-derived bicyclic aminals or norephedrine-derived oxazolidines. One auxiliary is used in the synthesis of an optically active ~-hydroxy pho
✦ LIBER ✦
Diastereoselective conjugate addition with acetals, oxazolidines and imidazolidines as chiral auxiliaries
✍ Scribed by A. Alexakis; R. Sedrani; P. Mangeney; J.F. Normant
- Book ID
- 104216635
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 202 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
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## Abstract A number of __N__‐acryloyl‐, __N__‐crotonoyl‐, __N__‐(3,3,3‐trifluorocrotonoyl)‐, __N__‐cinnamoyl‐, and __N__‐(3‐nitroacryloyl)‐4‐isopropyl‐ or ‐4‐phenyl‐oxazolidin‐2‐ones with __geminal__ diphenyl substitution, __i.e.__, **7**–**15**, have been prepared and used for conjugate additions