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Diastereoselective Approaches to trans-Hydrindan Derivatives — Total Synthesis of 8-(Phenylsulfonyl)de-A,B-cholestane Precursors to 25-Hydroxyvitamin D3.

✍ Scribed by Igor Prowotorow; Wiaczeslaw Stepanenko; Jerzy Wicha


Publisher
John Wiley and Sons
Year
2010
Weight
37 KB
Volume
33
Category
Article
ISSN
0931-7597

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Diastereoselective Approaches to trans-H
✍ Igor Prowotorow; Wiaczesław Stepanenko; Jerzy Wicha 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 177 KB

The total diastereoselective synthesis of the C,D rings/side chain building block for the synthesis of 1α,25-dihydroxyvitamin D 3 is described. Two tandem Mukaiyama-Michael additions involving silylated ketene acetals derived from tert-butyl 6-methylhept-5-enethioate or tert-butyl 6-methylhept-6enet