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ChemInform Abstract: New Diastereoselective Approach to trans-Hydrindan Derivatives. Synthesis of an 8-Phenylsulfonyl-A,B-descholestane Derivative, a Precursor to 25-Hydroxyvitamin D3.

✍ Scribed by K. MICHALAK; W. STEPANENKO; J. WICHA


Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis


Precursor to 25-Hydroxyvitamin D3. -The target vitamin D precursor (X) is synthesized in six steps with 31% overall yield. -(MICHALAK, K.;


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Diastereoselective Approaches to trans-H
✍ Igor Prowotorow; WiaczesΕ‚aw Stepanenko; Jerzy Wicha πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 177 KB

The total diastereoselective synthesis of the C,D rings/side chain building block for the synthesis of 1Ξ±,25-dihydroxyvitamin D 3 is described. Two tandem Mukaiyama-Michael additions involving silylated ketene acetals derived from tert-butyl 6-methylhept-5-enethioate or tert-butyl 6-methylhept-6enet