Diastereoselective Approaches to trans-H
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Igor Prowotorow; WiaczesΕaw Stepanenko; Jerzy Wicha
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Article
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2002
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John Wiley and Sons
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English
β 177 KB
The total diastereoselective synthesis of the C,D rings/side chain building block for the synthesis of 1Ξ±,25-dihydroxyvitamin D 3 is described. Two tandem Mukaiyama-Michael additions involving silylated ketene acetals derived from tert-butyl 6-methylhept-5-enethioate or tert-butyl 6-methylhept-6enet