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Diastereoselective addition of organolithiums to new chiral hydrazones. Enantioselective synthesis of (R)-coniine

✍ Scribed by Yong Hae Kim; Jun Young Choi


Book ID
103410677
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
229 KB
Volume
37
Category
Article
ISSN
0040-4039

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A New Asymmetric Synthesis of both Enant
✍ Enders, Dieter ;Tiebes, JΓΆrg πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 532 KB

## Abstract Both enantiomers of the hemlock alkaloid coniine 8 are prepared by asymmetric synthesis in 98% ee using only one enantiomer of the auxiliary. The key step of the synthesis consists in the 1,2‐addition of organoytterbium reagents to aldehyde SAMP hydrazones with virtually complete asymme