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Diastereocontrol in the asymmetric dihydroxylation of chiral 3-alkenyl-4,5-dihydroisoxazoles

โœ Scribed by Peter A. Wade; Damien T. Cole; Stephen G. D'Ambrosio


Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
282 KB
Volume
35
Category
Article
ISSN
0040-4039

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Kinetic resolution in the asymmetric dih
โœ Margaret A. Brimble; Andrew D. Johnston ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 1016 KB

The asymmetric dihydroxylation of unsaturated spiroacetals 1, 2, 3 was effected using the cinchona alkaloid ligands (DHQ)2-PHAL, (DHQD)2-PHAL and DHQ-IND, DHQD-IND with OsO4, K3Fe(CN)6 and methanesuffonamide. Kinetic resolution of the spiroacetals was achieved and the reactions were monitored by chi