Diastereo-differentiating simmons-smith reaction using 2,4-pentanediol as a chiral auxiliary
β Scribed by Takashi Sugimura; Tohru Futagawa; Akira Tai
- Book ID
- 104217631
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 333 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Ethyl 4,4-dimethylpyroglutamate has been used as a chiral auxiliary for ~,[3-unsaturated acids in Michael addition reactions. The conjugate addition of Grignard reagents to the amides in the presence of copper iodide, tetramethylene diamine (TMEDA) and trimethylsilyl chloride, proceeded with high yi
Asymmetric Michael Addition Reactions Using Ethyl (S)-4,4-Dimethylpyroglutamate as a Chiral Auxiliary. -High levels of diastereoselection are achieved by the use of (I) as chiral auxiliary for Ξ±,Ξ²-unsaturated acid chlorides (II) in Michael conjugated addition with Grignard-derived organocopper reag