𝔖 Bobbio Scriptorium
✦   LIBER   ✦

ChemInform Abstract: Asymmetric Michael Addition Reactions Using Ethyl (S)-4,4-Dimethylpyroglutamate as a Chiral Auxiliary.

✍ Scribed by Jesus Ezquerra; Lourdes Prieto; Carmen Avendano; Jose Luis Martos; Elena de la Cuesta

Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
30
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

✦ Synopsis

Asymmetric Michael Addition Reactions Using Ethyl (S)-4,4-Dimethylpyroglutamate as a Chiral Auxiliary.

-High levels of diastereoselection are achieved by the use of (I) as chiral auxiliary for Ξ±,Ξ²-unsaturated acid chlorides (II) in Michael conjugated addition with Grignard-derived organocopper reagents. The resulting Michael adducts (V) are hydrolyzed under basic conditions yielding the corresponding Ξ²-substituted carboxylic acids (VI).

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: (S)-Ethyl 4,4-Dimet
ChemInform Abstract: (S)-Ethyl 4,4-Dimethyl Pyroglutamate as a New β€œQuat” Chiral Auxiliary in Aldol Condensations.
✍ J. EZQUERRA; A. RUBIO; J. MARTIN; J. L. GARCIA NAVIO πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 29 KB

The title pyroglutamate (II) is found to be an excellent auxiliary in stereoselective aldol reactions. Remarkably, the stereogenic center of (II) is not altered during all the transformations and (II) can be regenerated after the process in 70% yield. -(EZQUERRA, J.;

ChemInform Abstract: Asymmetric Addition
ChemInform Abstract: Asymmetric Addition of Nucleophiles to C-1 Position of Isoquinolines Using (S)-Alanine Derivatives as Chiral Auxiliaries.
✍ Takashi Itoh; Kazuhiro Nagata; Michiko Miyazaki; Keiko Kameoka; Akio Ohsawa πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 35 KB πŸ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

ChemInform Abstract: Catalytic Asymmetri
ChemInform Abstract: Catalytic Asymmetric Addition of Dialkylzinc to 3,4-Dihydroisoquinoline N-Oxides Utilizing Tartaric Acid Esters as a Chiral Auxiliary.
✍ Yutaka Ukaji; Yuuko Shimizu; Yuuichi Kenmoku; Alauddin Ahmed; Katsuhiko Inomata πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 29 KB πŸ‘ 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v