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ChemInform Abstract: (S)-Ethyl 4,4-Dimethyl Pyroglutamate as a New “Quat” Chiral Auxiliary in Aldol Condensations.

✍ Scribed by J. EZQUERRA; A. RUBIO; J. MARTIN; J. L. GARCIA NAVIO

Publisher: John Wiley and Sons
Year: 2010
Weight: 29 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199730112

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✦ Synopsis

The title pyroglutamate (II) is found to be an excellent auxiliary in stereoselective aldol reactions. Remarkably, the stereogenic center of (II) is not altered during all the transformations and (II) can be regenerated after the process in 70% yield. -(EZQUERRA, J.;

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