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Dialkyltin derivatives of dicarboxylic acids: Synthesis, characterization and in vitro antitumor properties

✍ Scribed by Marcel Gielen; Mohammed Bouâlam; Abdelkader Meriem; Bernard Mahieu; Monique Biesemans; Rudolph Willem

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
329 KB
Volume
3
Category
Article
ISSN
1042-7163

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✦ Synopsis

Diorganotin deriuatiws of dicarboxylic acids, including diethyltin propene-l,3-dicarboxylate, diethyltin homophthalate, and di-n-butyltin tetrafluorophthalate, were tested in uitro against two human tumor cell lines, MCF-7, a mammary tumor, and WiDr, a colon carcinoma. Most of these display lower inhibition doses ID,, than cis-platin. The synthesis and characterization of the last three compounds by Mossbauer spectroscopy, 'H, I3C andlor Il9Sn NMR and mass spectrometry, are also presented.

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