Dialkyl Peroxide-Induced Reductions of Aromatic Ketones
β Scribed by Huyser, Earl S.; Neckers, Douglas C.
- Book ID
- 125911040
- Publisher
- American Chemical Society
- Year
- 1963
- Tongue
- English
- Weight
- 552 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0002-7863
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π SIMILAR VOLUMES
An efficient general method for the consecutive introduction of two alkyl groups to the ct carbon of a ketone carbonyl has been developed, making use of the lithium naphthalenide induced reductive alkylation of an ~t-cyano ketone system as a key operation.
Reduction of various ketones to their corresponding alcohols is shown to be instantaneous, i.e. completed in less than 10 s, by samarium diiodide (2.5 equiv.) in the presence of water (6.25 equiv.) and an amine (5 equiv.) in THF. The rates of reduction of ketones in this mixture exceed by far the ra