Diagnostic significance of allelic imbalance in cancer
β Scribed by Heaphy, Christopher M; Bisoffi, Marco; Griffith, Jeffrey K
- Book ID
- 120460364
- Publisher
- Informa plc
- Year
- 2007
- Tongue
- English
- Weight
- 177 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1753-0059
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Frequent allelic imbalance of polymorphic markers mapped to regions of the 7q, 8p, 16q, and 18q arms has been reported in prostate cancer. To better define the clinical significance of these genetic alterations, we undertook a retrospective analysis of systemic progression and survival in patients w
The PTEN/MMAC1/TEP1 tumor-suppressor gene, which maps to chromosome 10q23.3, is mutated and homozygously deleted in a variety of human tumors, including endometrioidtype ovarian tumors. We examined 33 primary ovarian cancers and 3 ovarian borderline tumors for allelic imbalance (AI) of the 10q23.3 r