Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry
✍ Scribed by Jørn V Sagen; Lise Bjørkhaug; Janne Molnes; Helge Ræder; Louise Grevle; Oddmund Søvik; Anders Molven; Pål R Njølstad
- Book ID
- 110905601
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 221 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1399-543X
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Maturity onset diabetes of the young (MODY) is a genetically heterogeneous form of type 2 diabetes that is characterized by autosomal dominant inheritance, onset in early adulthood and a primary defect in insulin secretion. Mutations in at least six genes have been shown to underlie MODY, including
## Maturity -onset diabetes of the young (MODY) resulting from mutations in the glucokinase (GCK) gene accounts for approximately 20% of MODY in the UK. W e have performed fluorescent single stranded conformation polymorphism (F-SSCP) analysis or direct sequencing of the GCK gene in 212 patients re