𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Diagnosis and staging of mild cognitive impairment, using a modification of the clinical dementia rating scale: the mCDR

✍ Scribed by Ranjan Duara; David A. Loewenstein; Maria T. Greig-Custo; Ashok Raj; Warren Barker; Elizabeth Potter; Elizabeth Schofield; Brent Small; John Schinka; Yougui Wu; Huntington Potter

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
126 KB
Volume
25
Category
Article
ISSN
0885-6230

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Objective

To examine the reliability and validity of the mCDR, a modified version of the clinical dementia rating (CDR) scale.

Methods

The mCDR is an informant‐based, technician‐administered, structured interview with multiple choice responses, which does not include objective cognitive testing. Subjects (n = 556) with no cognitive impairment (NCI), amnestic mild cognitive impairment (aMCI), and dementia were assessed with mCDR, CDR, and neuropsychological evaluation, while medial temporal atrophy (MTA) was measured on MRI scans. The mCDR and CDR were compared with respect to inter‐rater reliability, validity, and ability to predict progression in cognitive diagnosis at 12 month follow‐up.

Results

The mCDR can be administered in less than one third of the time required to administer the CDR (30 min). Inter‐rater reliability (Cohen's weighted κ) was 0.86 for the mCDR and 0.56 for the CDR. Ability to distinguish between NCI, aMCI, and Dementia subjects, and correlations to memory and non‐memory measures were marginally better for the CDR, in comparison to the mCDR. Correlations of mCDR and CDR scores to MTA scores did not differ. Baseline mCDR scores predicted transition from NCI to aMCI, whereas baseline CDR scores predicted transition from aMCI to Dementia.

Conclusions

The mCDR, as compared to the CDR, is briefer and more reliable, and is a valid measure of functional ability among subjects with normal cognition, mild cognitive impairment, and mild dementia. The mCDR should be particularly useful as a reliable and economical instrument for assessing change in functional abilities, especially in multi‐center clinical trials and population studies of MCI and mild dementia. Copyright © 2009 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

The clinical significance of subjective
The clinical significance of subjective memory complaints in the diagnosis of mild cognitive impairment and dementia: a meta-analysis
✍ Alex J. Mitchell 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 165 KB 👁 1 views

## Abstract ## Background Subjective memory complaints (SMC) are frequently reported by individuals with objective evidence of cognitive decline although the exact rate of complaints and their diagnostic value is uncertain. ## Method A meta‐analysis was conducted for all studies examining SMC an

DemTect: a new, sensitive cognitive scre
DemTect: a new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia
✍ E. Kalbe; J. Kessler; P. Calabrese; R. Smith; A. P. Passmore; M. Brand; R. Bullo 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 107 KB 👁 1 views

## Abstract ## Objectives To design a new, highly sensitive psychometric screening to identify patients with mild cognitive impairment (MCI) and patients with dementia in the early stages of the disease. ## Methods Five tasks were included in the DemTect: a word list, a number transcoding task,

Behavioral regulation: factor analysis a
Behavioral regulation: factor analysis and application of the Behavioral Dyscontrol Scale in dementia and mild cognitive impairment
✍ James R. Hall; Michelle B. Harvey 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 64 KB 👁 1 views

## Abstract ## Background Executive dysfunction is a hallmark of both Dementia of the Alzheimer's Type (AD) and Vascular Dementia (VaD). A complete neuropsychological battery contains measures of executive function, but the focus tends to be on cognitive processes with verbal or written output. Th

The validity of a caregiver-rated brief
The validity of a caregiver-rated brief behavior symptom rating scale (BSRS) for use in the cognitively impaired
✍ Peter V. Rabins 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 443 KB 👁 1 views

## Abstract The validity of a 12‐item brief behavioral symptom rating scale for use in the cognitively impaired was studied using nurse clinician ratings for criterion validity and the Brief Psychiatric Rating Scale and Behavioral Scale of the Psychogeriatric Dependency Rating Scale for convergent

Reliability and validity of a chronic ca
Reliability and validity of a chronic care facility adaptation of the Clinical Dementia Rating scale
✍ Deborah B. Marin; Sean Flynn; Marlene Mare; Melinda Lantz; Ming-Ann Hsu; Max Lau 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 65 KB 👁 2 views

## Objective: This study investigated the reliability and validity of a chronic care facility adaptation of the clinical dementia rating scale (cdr-cc). ## Method: Sixty-two residents in a chronic care facility participated in an inter-rater and 1 month test-retest reliability study. the instrume

CAMcog as a screening tool for diagnosis
CAMcog as a screening tool for diagnosis of mild cognitive impairment and dementia in a Brazilian clinical sample of moderate to high education
✍ Paula V. Nunes; Breno S. Diniz; Marcia Radanovic; Izabella D. Abreu; Danilo T. B 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 110 KB 👁 1 views

## Abstract ## Background The CAMCOG is a brief neuropsychological battery designed to assess global cognitive function and ascertain the impairments that are required for the diagnosis of dementia. To date, the cut‐off scores for mild cognitive impairment (MCI) have not been determined. Given the