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Diabetes as a disease of endoplasmic reticulum stress

✍ Scribed by Sally E. Thomas; Lucy E. Dalton; Marie-Louise Daly; Elke Malzer; Stefan J. Marciniak

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
230 KB
Volume
26
Category
Article
ISSN
1520-7552

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The unfolded protein response (UPR) is an evolutionarily conserved cell signaling pathway that is activated to regulate protein synthesis and restore homeostatic equilibrium when the cell is stressed from increased client protein load or the accumulation of unfolded or malfolded proteins. Once activ