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Dhh1 regulates the G1/S-checkpoint following DNA damage or BRCA1 expression in yeast1

โœ Scribed by T.J Westmoreland; J.A Olson Jr.; W.Y Saito; G Huper; J.R Marks; C.B Bennett


Book ID
117169408
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
710 KB
Volume
113
Category
Article
ISSN
0022-4804

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The protein kinase Chk1 is essential for the DNA damage checkpoint. Cells lacking Chk1 are hypersensitive to DNA-damaging agents such as UV light and -irradiation because they fail to arrest the cell cycle when DNA damage is generated. Phosphorylation of Chk1 occurs after DNA damage and is dependent