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Dextromethorphan Pretreatment Induces Antipyrine Clearance in the Rat

✍ Scribed by Craig K. Svensson; Joseph A. Ware

Book ID
114421065
Publisher
Springer US
Year
1988
Tongue
English
Weight
484 KB
Volume
05
Category
Article
ISSN
0724-8741

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A group of 15 rats received two intravenous bolus doses of antipyrine (15 mg/kg) separated by a 57 hour infusion (with bolus dose) of phenobarbital. Phenobarbital bolus doses and infusion rates were based on a preliminary pharmacokinetic study (7 rats) and were varied to achieve a broad range of ste