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Dexamethasone Modulates TCR ζ Chain Expression and Antigen Receptor-Mediated Early Signaling Events in Human T Lymphocytes

✍ Scribed by Madhusoodana P. Nambiar; Edith J. Enyedy; Carolyn U. Fisher; Vishal G. Warke; Yuang-Taung Juang; George C. Tsokos


Book ID
112240383
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
202 KB
Volume
208
Category
Article
ISSN
0008-8749

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High dose of dexamethasone upregulates T
✍ Madhusoodana P. Nambiar; Edith J. Enyedy; Carolyn U. Fisher; Vishal G. Warke; Ge 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 315 KB

Glucocorticoids are very potent anti-in¯ammatory and immunosuppressive agents that modulate cellular immune responses, although, the molecular mechanisms that impart their complex effects have not been completely de®ned. We have previously demonstrated that dexamethasone (Dex), a synthetic glucocort