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Dexamethasone-induced growth hormone release: A dose-response study

✍ Scribed by Jogin H. Thakore; Timothy G. Dinan

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
306 KB
Volume
8
Category
Article
ISSN
0885-6222

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✦ Synopsis

Glucocorticoids have recently been shown to acutely stimulate growth hormone secretion in man. The aim of OUT study was to investigate the acute effects of three graded doses of dexamethasone. Six healthy male volunteers received in random order placebo, 1, 2 or 4 mg of oral dexamethasone. Mean stimulated growth hormone levels were significantly higher after 2 and 4 mg of DEX than after 1 mg or placebo. We conclude that dexamethasone used in lower doses than previously reported appears to stimulate growth hormone release in a dose dependent manner.

KEY worn-Growth hormone, dexamethasone, dose response.

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